HPV vaccination: Gardasil, Gardasil-9

Gardasil is a vaccine designed to prevent infections caused by the human papillomavirus (HPV). It provides protection against four types of the virus: 6, 11, 16, and 18, which are the primary causes of cervical cancer and genital warts.

Gardasil-9 is an advanced version of the vaccine that protects against nine HPV types: 6, 11, 16, 18, 31, 33, 45, 52, and 58.

Cervical cancer is a malignant tumor that develops in the cervix, which connects the uterus and the vagina. It is one of the most common cancers among women, particularly in developing countries. The primary cause of cervical cancer is an infection with human papillomavirus (HPV). Prevention of cervical cancer includes regular medical check-ups and screenings (Pap tests), as well as HPV vaccination. Gardasil and Gardasil-9 protect against the most dangerous types of HPV and are recommended for both children and adults of both sexes. In addition, HPV can cause genital warts, which can be a source of discomfort.

Indications for Gardasil and Gardasil-9 vaccines

• Prevention of HPV-associated diseases in girls and women aged 9 to 45 years
• Prevention of HPV-associated diseases in boys and men aged 9 to 45 years

Vaccination is especially important before the onset of sexual activity but can also be beneficial for those who have already become sexually active.

Mechanism of action

Both Gardasil and Gardasil-9 function through active immunization. After administration, virus-like particles in the vaccine stimulate the immune response, leading to the production of antibodies against HPV. The immune system then “remembers” these pathogens and the corresponding antibodies, ensuring long-term protection against infections caused by these HPV types.

HPV vaccination is an effective and essential step in preventing HPV-related diseases, particularly cervical cancer.